Evaluation of Free Radical Scavenging and Antioxidation Capacity of Resveratrol and Polydatin

摘要

Cellular damage induced by free-radicals like reactive oxygen species (ROS) has been implicated in several diseases. The ROS radicals like alkoxy radical (RO-) and peroxy radical (ROO-) are similar to those that are physiologically active and thus might initiate a cascade of intracellular toxic events leading to DNA damage and cell death. Hence naturally anti-oxidant play a vital role in combating these conditions. Resveratrol (RES) and polydatin (PD) are two kinds of natural phytoalexin with excellent antimicrobial and anti-inflammatory activity. In this study aim to evaluation of free radical scavenging and antioxidation capacity of Res and PD to provide a basis for the potential application and development in the future. The free radical scavenging and antioxidant ability were comprehensively evaluated by different systems, including the scavenging rates of DPPH, ABTS radical, hydrogen peroxide scavenging, lipid peroxidation inhibition abilities. The results showed that PD is significantly stronger than RES in DPPH~· scavenging, hydrogen peroxide scavenging and lipid peroxidation (P < 0.05), but RES is significantly stronger than PD in ABTS radical scavenging activity (P<0.05). RES and PD show their respective antioxidant activity advantages under different indicators, which means we should choose RES or PD according to the different uses.