Synthesis and in vitro Anti-ulcer Effect of Bisabolangelone Oxime Ether Derivatives

摘要

Four bisabolangelone oxime ether derivatives were synthesized and separated as potential anti-ulcer agents. Their structures were characterized by NMR, IR and ESI-MS. Preliminarily H~+/K~+-ATPase activity evaluation indicated that all the target oxime ethers exhibited the better H~+/K~+-ATPase inhibitory activities than the commercial omeprazole with the IC_(50) of 17-46 μM. These compounds might be used as potential anti-ulcer agents in the treatment of acid-related diseases.