Functional Effects of Polyphenol Metabolites Produced by Colonic Microbiota in Colon Cells In Vitro

摘要

Polyphenols can act pro- or anti-oxidatively, affect signal transduction pathways and thus may play an important role in colon cancer development. Studies with healthy ileostomy patients have pointed out that after apple juice intake most of the ingested polyphenols reached the end of the small intestine and hence also the colon. After entering the colon, polyphenols are subject to metabolism by the human gut microbiota. The interest in these fermented gut products and their role in colon carcinogenesis is rapidly growing due to simulating the physiological conditions more than working with pure apple polyphenols in vitro. The modulation of biotransformation is one mechanism to modulate toxicity of endogenous compounds and xenobiotics. The aim of this study was to determine the effect of polyphenol metabolites formed in the human gut on parameters important for chemoprevention: Modulation of genes involved in detoxification and inflammation processes, cell number and DNA damage.