The invention is directed to the use of a microfluidic cell culture device for performing dietary compounds - host microbiota cells molecular interactions, said microfluidic cells culture device comprising two or more channels, wherein at least two adjacent channels are cell culture channels separated by a permeable or semi permeable membrane adapted to prevent passage of cells thereacross, a first channel of the at least two adjacent channels supporting a culture of microbiota cells of a host and a second of the at least two channels supporting at least one probiotics culture and being perfused with a medium of dietary compound.
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