MICROFLUIDIC IN VITRO MODEL FOR ELUCIDATING THE MOLECULAR EFFECTS OF SIMULATED DIETARY REGIMENS ON GUT MICROBIOTA AND HOST CELLS

摘要

A microfluidic cell culture device for performing dietary compounds—host microbiota cells molecular interactions, the microfluidic cells culture device comprising two or more channels, wherein at least two adjacent channels are cell culture channels separated by a permeable or semi permeable membrane adapted to prevent passage of cells thereacross, a first channel of the at least two adjacent channels supporting a culture of microbiota cells of a host and a second of the at least two channels supporting at least one probiotics culture and being perfused with a medium of dietary compound.