Design of Histone Deacetylase Inhibitors with Chlamydocin Framework containing Various Imino Acids instead of Proline Residue

摘要

The cyclic tetrapeptide chlamydocin, originally isolated from fungus Diheterospora chlamydosphoria, is one of the naturally-occurring inhibitors of histone deacetylases [1]. Strucure of chlammydocin is cyclo(-L-Aoe-Aib-L-Phe- D-Pro-), where Aoe is L-amino-8-oxo-9,10-epoxydecanoic acid. Recently we have synthesized and tested histone deacetylase inhibitory activities of chlamydocin hydroxamic acid analogs [2,3].