Fast and Selective N-Alkylation on Solid Support for SAR Studies and Functionalization of Peptidic CXCR4 Antagonists

摘要

Peptidic antagonists of the chemokine receptor CXCR4 have already shown anti-metastatic, anti-HIV and anti-rheumatoid arthritic activity [1], which represents a promising novel approach for therapeutic intervention in these diseases. Therefore, development of potent and optimized CXCR4 antagonists is an important requirement for the therapeutic success of this approach.