Separated anti-CxCR4 antibodies or one of their functional components; encrypted nucleic acid; vectors containing such nucleic acid; cell failure containing such vectors; production procedures; components containing such vectors; components used to prevent or treat HIV infection; and Roceedition for study and/or identification of CXCR4 for the study and/or identification of antiviral molecules

摘要

The present invention relates to isolated antibodies, or the derived compounds or functional fragments of same, capable of binding to CXCR4 but also of inducing conformational changes of the CXCR4 homodimers and able to inhibit HIV-1 primary isolate replication in PBMC. More particularly, the present invention relates to the 515H7 and 301aE5 monoclonal antibodies, specific to the CXCR4 protein, as well as their use for the treatment of HIV infection. Pharmaceutical compositions composed of such antibodies and a process for the selection of such antibodies are also covered.