From Drug Cocktails to Tissue Engineering: Synthesis of ROMP Polymers for Biomedical Applications

摘要

Challenges and advances in the synthesis of ring-opening metathesis polymerization (ROMP) polymers bearing biologically relevant functionalities are examined. The impact of various initiators, monomer platforms, and reaction conditions on control over polymer chain lengths and architectures, is discussed. Particular attention is given to the level of control currently attainable in Rupromoted ROMP of unprotected monomers in aqueous or protic media, vs. ROMP of protected monomers in organic solvents.