PREPARATION OF CARRIER-FREE METHYL-3HMETHYL NOSYLATE AND ITS USE AS A RADIOCHEMICALLY-STABLE METHYLATING REAGENT

摘要

Carrier-free [methyl-3H] methyl iodide is a powerful methylating reagent; however, it must be used soon after it is synthesized, as it degrades rapidly. We wished to extend the useful lifetime of the labeled methyl group by increasing its chemical stability. Transfer of the methyl group from iodide to benzenesulfonate derivatives gave methylating reagents which had a much longer useful lifetime than the parent [methyl-3H] methyl iodide with no loss of specific activity. Described are the preparation and reactions of [methyl-3H] methyl para-toluenesulfonate (1) and [mefhyl-3H] methyl para-nitrobenzenesulfonate (2).