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Process for the preparation of carrier-free high-purity 177Lu compounds and carrier-free 177Lu compounds

机译:无载体高纯度177Lu化合物和无载体177Lu化合物的制备方法

摘要

The present invention relates to a column chromatographic method for preparing carrier-free, high purity 177Lu compounds for medical use. In the method according to the invention, a cation exchanger and a suitable complexing agent are used. With the method according to the invention it is possible for the first time, from 176Yb compounds irradiated with thermal neutrons, wherein the radionuclides 177Lu and 176Yb are present for the purification in a mass ratio of about 1: 102 to 1: 1010, carrier-free, high purity 177Lu compounds in milligrams for pharmaceutical-medical purposes in a highly purified form.
机译:本发明涉及一种用于制备医学上无载体的高纯度177Lu化合物的柱色谱方法。在根据本发明的方法中,使用阳离子交换剂和合适的络合剂。利用根据本发明的方法,有可能第一次从用热中子辐照的176Yb化合物中,其中放射性核素177Lu和176Yb用于纯化的质量比为约1:102至1:1010,以毫克为单位的游离,高纯度的177Lu化合物,高度纯化形式可用于药物医学。

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