A variety of functional studies have emphasized the importance of the medial temporal lobe (MTL) and prefrontal cortex (PFC) for episodic and working memory, respectively. We investigated the structural basis of information transfer from MTL to PFC in primate cerebral cortex using the CoCoMac database (www.cocomac.org), coordinate-independent mapping procedures, and multivariate statistics. In our meta-analysis, we found a clearly decreasing gradient of MTL projections to PFC: strongest from periallocortical regions and weakest from hippocampus proper. These projections roughly divide the PFC into medial and lateral groups of areas.
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