KNOCKOUT MOUSE, SCREENING METHOD FOR MATERIAL TO SUPPRESS MEDIAL TEMPORAL LOBE EPILEPSY, AND SELECTION METHOD FOR TECHNIQUE TO SUPPRESS MEDIAL TEMPORAL LOBE EPILEPSY

摘要

PROBLEM TO BE SOLVED: To provide a knockout mouse used for screening a material and/or a technique to suppress medial temporal lobe epilepsy.SOLUTION: There is provided a knockout mouse used for screening a material and/or a technique to suppress medial temporal lobe epilepsy in which the function of the Girdin gene is lost, and which exhibits phenotypes of (1) to (3): (1) hippocampal sclerosis is seen, (2) brain damage other than the damage to the hippocampus is limited, and (3) spontaneous epilepsy which can be said to have originated from the hippocampus is seen.SELECTED DRAWING: Figure 6