Knockout mouse, screening method for substances that suppress medial temporal lobe epilepsy, and method for selecting technique for suppressing medial temporal lobe epilepsy

摘要

Disclosed is a knockout mouse used for screening a substance and / or technique for suppressing medial temporal lobe epilepsy. A knockout mouse used for screening a substance and / or a technique that suppresses medial temporal lobe epilepsy, wherein the function of the Girdin gene is lost and the following phenotypes (1) to (3) are exhibited: . (1) Have hippocampal hardening. (2) Brain damage outside the hippocampus is limited. (3) There is spontaneous epilepsy that can be said to be of hippocampal origin. [Selection] Figure 6