Preparation and Controlled Release of Chitosan Nanoparticles Loading Ginsenoside Rg1

摘要

Nanoparticles have been widely investigated as a carrier for drug delivery. Nanoparticles are good candidates for drug carrier to deliver drugs, because they are expected to be adsorbed in an intact form in the gastrointestinal tract after oral administration1. Chitosan with excellent biodegradable and biocompatible characteristics, is a naturally occurring polysaccharide. Chitosan has been examined extensively in the pharmaceutical industry for its potentialin the development of drug delivery systems2-3, because of its mucoadhesivity and ability to enhance the penetration of drugs across mucosal surface. Tripolyphosphate (TPP) is a polyanion, and can interact with cationic chitosan by electrostatic forces4. In Chinese traditional medicine research area, human have special interest in research nanoparticles based on chitosan-TPP crosslinking. Ginsenoside Rg1 was distilled from a kind of Chinese traditional medicine named KANG'AISAN. The aim of this study was to prepare Ginsenoside Rg1 nanoparticles based on different concentration of chitosan and TPP, to investigate their encapsulation efficiency, and to provide basic data for Ginsenoside Rg1 release from nanoparticles.