Development of Blood Compatible Alpha-lipoic acid Coated Stent with a Good Adhesive by Low Temperature Plasma Polymerization

摘要

Neointimal hyperplasia is a main cause for in-stent restenosis after stent-implantation and is triggered by inflammatory response to foreign materials. It can be inhibited if the stent is modified to have good blood compatibility by coating drug compounds. Low temperature plasma polymerization of 1,2-diaminocyclohexane was performed to prepare more adhesive polymeric thin film onto the metallic stent. Then, the chemical grafting of a-lipoic acid (ALA) was carried out to improve blood compatibility of stent. Drugs containing carboxylic groups can be chemically grafted through the formation of amide bond in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide methiodide onto the DACH deposited stent surface. ALA grafted film showed good mechanical stability and blood compatibility.