Synthesis of Gadolinium-doped Fluorescent Au/Ag Nanoclusters as Bimodal MRI Contrast Agents

摘要

In this presentation synthesized the T1 contrast agent, combinations of MRI and optical imaging modalities will be introduced. Using bovine serum albumin conjugated with gadolinium and fluorescence gold or silver nanoclusters (Fluorescence gold /silver protein). An average of 34 Gd-DTPA chelates were covalently conjugated to bovin serum albumin. The T1 relaxivity of BSA-Gd-DTPA was 163.27mM~(-1) sec~(-1). The experimental results shows a new dual-modal imaging agent of fluorescent gold/silver protein with a paramagnetic in vitro and in vivo, which can be hold many potential applications in medical diagnostics and therapy.