Immune system modelling in ease of a septic shock

摘要

A dynamical pathophysiological model is presented in the case of septic shock.The proposed approach takes into account the environment and the different subsystems.The considered immune system is the blood, the subsystems are leukocyte cells and cytokines.The interactions between blood cells, plasma and the environment are described via mass balances.The transport phenomena between cells and blood and thermodynamic equilibrium are considered.The quantities of pro and anti-cytokines present in the body are combined to propose global information on the inflammatory state of the patient.The proposed model is strongly nonlinear.Simulations showed how the global information evolves after septic shock.In particular, the model has the ability to evolve to alternative homeostatic equilibrium in case of septic shock.