Development of an alphavirus RNA particle-based vaccine against porcine epidemic diarrhea virus

摘要

Porcine epidemic diarrhea (PED), which recently emerged in the United States, is characterized by acute diarrhea and dehydration in both suckling and finishing pigs.1,2 The disease is caused by a coronavirus, porcine epidemic diarrhea virus (PEDV). Losses due to PED can be severe, and there is a need for efficacious vaccines.Alphavirus-derived replicon particles (RP) are propagation defective, single-cycle expression vectors that have been established as a safe and effective vaccine platform for swine.3 The RP platform has previously been used to develop effective vaccines for other coronaviruses, notably SARS-CoV. In response to the urgent need for effective vaccines, Har-risvaccines is developing RP-based PED vaccines.