Phenyl(cyclo)alkylamines: Second generation P1' position analogs for pentapeptidic BACE1 inhibitors

摘要

In continuation of our efforts to overcome the acidity of the pentapeptidic BACE1 inhibitors, recently we identify new P1' position analogs by bioisosteric replacement of the 3-amino benzoic acid. Here we report phenyl(cyclo)alkylamines as a new non-acidic and hydrophobic residue at the P1' position.