Quantitative proteome analysis of doxorubicin resistance in ovarian cancer cells using SILAC

摘要

Multiple signal path ways may participate in the doxorubicin-resistance of ovarian cell, such as DNA synthesis, RNA synthesis and protein metabolism. Mitotracker staining of mitochondria in the two cell lines and observation with confocal laser scanning microscopy revealed that the shape and subcellular distribution of mitochondria were greatly changed in the doxorubicin resistance cell line, which indicated that mitochondria were main targets of doxorubicin resistance in ovarian cells.