Validation of a Method for the Determination of Lapatinib in Human Plasma by LC-MS/MS

摘要

Lapatinib functions as an inhibitor to the EGFR and erbB-2 receptors. These specific receptors are part of the Type I receptor kinase family involved in cell proliferation. Because cells with inactive Type I receptors don't exhibit uncontrolled growth, it is believed that an inhibitor of erbB kinases could be useful in inhibiting uncontrolled cell growth via stasis or cell death. Presented here is the validation of an LC/MS/MS assay for lapatinib in human plasma.