Design, Synthesis and Test of Novel Lipidated Cysteine Analogs as Efficient TLR2/6 Agonists

摘要

Synthetic vaccines use synthetic molecules as antigens for vaccination. Since real pathogens are no longer needed in synthetic vaccines, they are considered safer than the traditional inactivated or attenuated vaccines. The development of synthetic vaccines can be achieved on the genome sequence of the pathogen, which is much more efficient than the traditional way of sampling pathogens from the outbreak and grow cultures. Despite these advantages, the development of synthetic vaccines is hindered by the poor immunogenicity of synthetic antigens and the lack of effective adjuvants that enhance immune responses [2].