NOVEL TUMOR-TARGETED PEPTIDE-CAMPTOTHECIN CONJUGATES; SYNTHESIS AND BIOLOGICAL EVALUATION

摘要

Small peptides have been used in literature, for targeting antitumoral drugs to specific membrane receptors over-expressed by tumor cells, such as somatostatin, bombesin, RGD peptide analogues and peptidomimetics. RGD peptides, that selectively recognize α_vβ3 and α_vβ5 integrin receptors, appear attractive candidates. Due to the role of integrins in the angiogenesis and tumor growing , tumor-targeted RGD peptide-cytotoxic drug conjugates are likely to exhibit a dual antitumor and antiangiogenic effect.