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Coupling of ion mobility and mass spectrometry as a new alternative for the analysis of pharmaceutical diastereomers

机译：离子迁移率和质谱的偶联作为药物非对映异构体分析的新替代方案

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IM-MS allows to obtain information about conformation in gas phase of pharmaceutical diastereomers of the diarylquinoline chemical family. This fast method enables the differentiation of diastereomers by the measurement of their drift time and permits to determine the values of collision cross section.

机译：IM-MS允许获得关于二芳基喹啉化学家族的药物非对映异构体的气相构象的信息。这种快速方法通过测量它们的漂移时间和允许确定碰撞横截面的值来实现非对映异构体的分化。

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《International Mass Spectrometry Conference》|2014年||共1页
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Laurence Queguiner; Virginie Domalain; David Speybrouck; Marie Hubert-Roux; Eric Arnoult; Carlos Afonso; Jerome Guillemont;
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中图分类分析化学;
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专利

1. Coupling trapped ion mobility spectrometry to mass spectrometry: trapped ion mobility spectrometry–time‐of‐flight mass spectrometry versus trapped ion mobility spectrometry–Fourier transform ion cyclotron resonance mass spectrometry [J] . Tose Lilian V., Benigni Paolo, Leyva Dennys, Rapid Communications in Mass Spectrometry: RCM . 2018,第15期

机译：耦合捕获的离子迁移谱法质谱法：捕获离子迁移光谱 - 飞行时间的飞行时间质谱法与捕获离子迁移光谱 - 傅里叶变换离子回旋谐振质谱法
2. Ultra high performance liquid chromatography-time-of-flight high resolution mass spectrometry in the analysis of hexabromocyclododecane diastereomers:Method development and comparative evaluation versus ultra high performance liquid chromatography coupled to Orbitrap high resolution mass spectrometry and triple quadrupole tandem mass spectrometry [J] . D. Zacs, J. Rjabova, I. Pugajeva, Journal of chromatography, A: Including electrophoresis and other separation methods . 2014,第Null期

机译：六溴环十二烷非对映异构体分析中的超高效液相色谱-飞行时间高分辨率质谱：与Orbitrap高分辨率质谱和三重四极杆串联质谱联用的超高效液相色谱法的方法开发和比较评估
3. Ion mobility-mass spectrometry analysis of diarylquinoline diastereomers: Drugs used for tuberculosis treatment [J] . Domalain Virginie, Hubert-Roux Marie, Queguiner Laurence, European journal of mass spectrometry . 2019,第3期

机译：二芳基喹啉非对映异构体的离子迁移率 - 质谱分析：用于结核治疗的药物
4. Coupling of ion mobility and mass spectrometry as a new alternative for the analysis of pharmaceutical diastereomers [C] . Laurence Queguiner, Virginie Domalain, David Speybrouck, International Mass Spectrometry Conference . 2014

机译：离子迁移率和质谱的偶联作为药物非对映异构体分析的新替代方案
5. Part I: Pharmaceutical analysis of selected drugs using HPLC and mass spectrometry. Part II: Pharmaceutical analysis of selected drugs using capillary electrophoresis. [D] . Xu, Xiaohui. 2000

机译：第一部分：使用HPLC和质谱分析选定药物的药物。第二部分：使用毛细管电泳对选定药物进行药物分析。
6. Chiral Separation of Diastereomers of the Cyclic Nonapeptides Vasopressin and Desmopressin by Uniform Field Ion Mobility Mass Spectrometry [O] . Shawn T. Phillips, James N. Dodds, Berkley M. Ellis, -1

机译：均匀场离子迁移质谱法手性分离环状九肽加压素和去氨加压素的非对映异构体
7. Coupling trapped ion mobility spectrometry to mass spectrometry: trapped ion mobility spectrometry–time‐of‐flight mass spectrometry versus trapped ion mobility spectrometry–Fourier transform ion cyclotron resonance mass spectrometry [O] . Lilian V. Tose, Paolo Benigni, Dennys Leyva, 2018

机译：耦合捕获的离子迁移率光谱法质谱：捕获离子迁移光谱 - 飞行时间的飞行时间质谱法与捕获的离子迁移光谱 - 傅里叶变换离子回旋谐振质谱法

Coupling of ion mobility and mass spectrometry as a new alternative for the analysis of pharmaceutical diastereomers

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