Trace level quantitative determination of phthalates from high risk dosage pharmaceutical formulations using LC/MS/MS

摘要

The theoretical AET for all the sample considering Safety Concern Threshold (SCT) as 0.15μg/day is found to be around 2 μg/mL i.e. 2000 ppb, whereas the estimated AET using this sample preparation method is about 1μg/mL i.e. 1000 ppb. LOQ in the range of 1 ppb to 10 ppb was achieved for different phthalates which is well below the Estimated AET level.