A QUANTUM-CHEMICAL APPROACH TO THE AMINO ANALOGS OF FIREFLY LUCIFERIN

摘要

Various analogs of the substrate luciferin (Ln-OH) were used in order to study how in vitro firefly bioluminescence has the high quantum yield and wide spectral distribution of emission through the characteristic interaction with the wild-type luciferase (PpyLuc) from North American firefly (Photinus pyralis). White et al have synthesized the amino analogs of Ln-OH substituting its 6'-OH group by amino derivatives, namely amino luciferin (la), acetylaminoluciferin (Ib), trifluoroacetyl amino luciferin (Ic).