Development of recyclable and environmentally friendly palladium catalyst supported on sulfur-terminated gallium arsenide (001) into Suzuki-Miyaura coupling

摘要

Suzuki-Miyaura coupling is a particularly important reaction in organic chemistry, since it is the most powerful tool for a constructing a biaryl structure, which is found many biologically active compounds. Therefore, Suzuki-Miyaura coupling is frequently used in the synthesis of natural products and drugs. However, when homogeneous palladium catalysts, such as Pd(OAc)2, Pd(PPh3)4, and Pd(dba)2, are used in the synthesis of fine chemical products, we must address the problem of residual metal in the product. Furthermore, an expensive palladium is wasted and can not be reused. To overcome these problems, immobilized palladium catalysts have been developed for carbon-carbon bond formation, and highly active heterogeneous catalysts have been reported. Nevertheless, the development of catalysts combine both low leaching and high recyclability is an ongoing challenge.