Using capillary electrophoresis to study methylation effect on RNA-peptide interaction

摘要

Pottranscriptional and posttranslational modifications of RNAs and proteins are not well understood mechanisms of gene expression regulation.Methylation is the simplest modification known.Modified residue (nucleoside ora mino acid)-dependent RNA-protein interaction is difficult to study because of inherent problems in isolation,chemical synthesis and characterization of interaction between functional biomolecules.