A structure-activity study of D-Ala~8-dynorphin-(1-11)-peptide amide.Synthesis of analogues with modified amino acids in positions of 0,1,3,7

摘要

Dynorphin A,(Dyn A) a heptadecapeptide isolated from porcine pituitary,preferentially interacts with the k opioid receptor and therefore is postulated to be an endogenous ligand for these receptors [1].Dyn A shares a common N-terminal t etrapetpide sequence (the "message" sequence) with other mammalian opioid peptides,while containing a unique C-terminal "address" sequence which imparts selectivity for k opioid receptors.