Effect of the amino acid substituents on amide obnd cleavage in N-acyl-alpha,alpha-dialkylglycine derivatives

摘要

alpha,alpha-Dialkylglycine and their peptides have attracted considerable attention,as they show unique biological activities and very stable secondary structures.In previous work,we have reported that the amide bond at the C-terminal of a series of alpha,alpha-dialkylglycine derivatives such as Deg,Dpg,D_ibg and Db_zg is labile to acid;cleavage was achieved by reaction with neat TFA,the products being obtianed by aqueous work-up [1].