Design and synthesis of novel pure motilin antagonists

摘要

Motilin is a 22 amino acid gastrointestinal (GI) peptide which stimulates contractile activity of gastrointestinal smooth muscle.Recently,it was suggested that motilin may be involved in the production of some GI symptoms,such as early satiety,abdominal distention,nausea,vomiting,and anorexia,suggesting that motilin antagonists may have clinical applications.