where: y - ; Ar - phenyl; x = 0 or 1; X - hydrogen, hydroxyl, acetoxy or acylamino-group; m = 2 or 3; Ar - phenyl or naphthyl; n = 0, 1, 2 or 3; p = 1 or 2 at condition that when p = 2 then n = 1 and Q - two oxygen atoms; Q - oxygen or two hydrogen atoms; T - -C(O)- or -CH2-; q = 0 or 1; Z - phenyl. Reagent 1: compound of the formula (II) . Reagent 2: HOC(O)-(CH2)q or Hal-(CH2)q+1-Z where Hal - halogen; E - hydroxyl or O - protected group. From the synthesized compound (III) the protected group is split and treated with CH3SO2Cl and the secondary amine of the formula (IV) . Synthesized compounds were used in medicine as antagonists of neurokinin receptors. EFFECT: improved method of synthesis. 13 cl, 8 tbl"/>
POLYCYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS, METHOD OF SYNTHESIS OF POLYCYCLIC AMINE-CONTAINING COMPOUNDS, CYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO NEUROKININ RECEPTORS
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POLYCYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS, METHOD OF SYNTHESIS OF POLYCYCLIC AMINE-CONTAINING COMPOUNDS, CYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO NEUROKININ RECEPTORS
POLYCYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS, METHOD OF SYNTHESIS OF POLYCYCLIC AMINE-CONTAINING COMPOUNDS, CYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO NEUROKININ RECEPTORS
FIELD: organic chemistry. SUBSTANCE: products: polycyclic amine-containing compounds of the formula (I) where: y - ; Ar - phenyl; x = 0 or 1; X - hydrogen, hydroxyl, acetoxy or acylamino-group; m = 2 or 3; Ar - phenyl or naphthyl; n = 0, 1, 2 or 3; p = 1 or 2 at condition that when p = 2 then n = 1 and Q - two oxygen atoms; Q - oxygen or two hydrogen atoms; T - -C(O)- or -CH2-; q = 0 or 1; Z - phenyl. Reagent 1: compound of the formula (II) . Reagent 2: HOC(O)-(CH2)q or Hal-(CH2)q+1-Z where Hal - halogen; E - hydroxyl or O - protected group. From the synthesized compound (III) the protected group is split and treated with CH3SO2Cl and the secondary amine of the formula (IV) . Synthesized compounds were used in medicine as antagonists of neurokinin receptors. EFFECT: improved method of synthesis. 13 cl, 8 tbl
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机译：领域：有机化学。物质：产品：式（I）的含多环胺的化合物其中：y- ; Ar-苯基; x = 0或1; X-氢，羟基，乙酰氧基或酰氨基; m = 2或3; Ar-苯基或萘基; n = 0、1、2或3; p = 1或2，条件是当p = 2时n = 1且Q-两个氧原子; Q-氧或两个氢原子; T--C（O）-或-CH 2 -; q = 0或1; Z-苯基。试剂1：式（II）的化合物。试剂2：HOC（O）-（CH 2 ） q 或Hal-（CH 2 ） q + 1 -Z其中Hal-卤素; E-羟基或O-保护基。从合成的化合物（III）中拆分受保护的基团并用CH 处理3 SO 2 Cl和式（IV）的仲胺<图像文件=“ 00000007.GIF” he =“ 12” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 20” />。合成的化合物在医学上用作神经激肽受体的拮抗剂。效果：改进的合成方法。 13厘升，8汤匙
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