Exposures Related to Marijuana use by Smoking, Vaping, and Ingesting

摘要

Abstract: Ten marijuana users were studied in a metabolic ward following controlled smoking, vaping, and ingesting of marijuana products. Study participants were restricted to non-tobacco smokers so that tobacco exposures did not confound marijuana exposures. Urine samples collected before and at multiple times after each exposure will be assayed for cannabinoids (5 metabolites), nicotine (7 metabolites), volatiles (6 metabolites), PAHs (9 metabolites), heterocyclic amines (7 metabolites), and creatinine. Exposure doses will be calculated for cannabinoids, and exposure to harmful combustion products will be discussed in the context of potentially harmful exposures to active users. Potential exposure from secondhand and thirdhand marijuana smoke exposure will also be discussed.