A Circuit Model for Bio-chemical Cell Signaling Receptor Protein and Phosphorylation Cascade pathway

摘要

Communication between cells in multicellular organisms such as animals, humans and plants is essential for co-ordinating the organismic activities of fertilization, growth, survival and reproduction. This biochemical communication between trillions of cells in organisms can be more complex than the Internet. This paper develops a CMOS circuit model of signal reception and signal transduction within a cell in response to extra-cellular molecular signals. The model converts the chemical signaling pathway into a CMOS multi-step logical transformation cascade. This modeling technique leads to understanding cellular malfunctions (diseases) in the form of logical (electrical) faults in a circuit.