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Biocompatible encapsulation and interconnection technology for implantable electronic devices

机译:可植入电子设备的生物相容性封装和互连技术

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A biocompatible packaging process for implantable electronic systems is under development at imec, combining biocompatibility, hermeticity, extreme miniaturization and cost aspects. In a first phase of this packaging sequence, hermetic chip sealing is performed by encapsulating all chips to realize a bi-directional diffusion barrier preventing body fluids to leach into the package causing corrosion, and preventing IC materials such as Cu to diffuse into the body, causing various adverse effects. For cost effectiveness, this chip sealing is performed as post-processing at wafer level, using modifications of standard clean room (CR) fabrication techniques. Well known conductive and insulating CR materials are investigated with respect to their biocompatibility, biostability, diffusion barrier properties and sensitivity to corrosion. Material selection and integration aspects are modified until good properties are obtained. In a second phase of the packaging process, all chips of the final device should be electrically connected, applying a biocompatible metallization scheme. We selected the use of Pt due to its excellent biocompatibility and corrosion resistance. Since Pt is very expensive, a cost effective Pt-selective plating process is developed. During the third packaging step, all system components such as electronics, passives, a battery,... will be interconnected. To provide sufficient mechanical support, all components are finally embedded using a medical grade elastomer such as PDMS or Poly-urethane.
机译:用于可植入电子系统的生物相容性包装工艺在IMEC下开发,使生物相容性,密闭性,极端小型化和成本方面组合。在该包装序列的第一阶段中,通过封装所有芯片来实现密封芯片密封以实现双向扩散屏障防止体液浸入包装中引起腐蚀的,并且防止诸如Cu的IC材料扩散到身体中,引起各种不利影响。为了成本效益,使用标准洁净室(CR)制造技术的修改,该芯片密封作为晶片级的后处理进行。众所周知的导电和绝缘Cr材料是关于它们的生物相容性,生物性,扩散阻挡性能和对腐蚀的敏感性的研究。修改了材料选择和集成方面,直到获得了良好的属性。在包装工艺的第二阶段中,最终装置的所有芯片应电连接,施加生物相容性金属化方案。由于其优异的生物相容性和耐腐蚀性,我们选择了PT的使用。由于PT非常昂贵,因此开发了成本有效的PT选择性电镀工艺。在第三包装步骤中,所有系统组件如电子,无源,电池,......将互连。为了提供足够的机械支撑,最终使用诸如PDMS或聚氨酯的医疗级弹性体嵌入所有组分。

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