Prediction of Drug Application Optimization Based on RBC Dynamics in Maintenance Chemotherapy of Acute Lymphoblastic Leukemia Maintenance

摘要

Acute lymphoid leukemia (ALL), a common childhood cancer has a high rate of disease relapse problem. In clinic it is generally treated with three stages-intensive chemotherapy, consolidation stage and finally a maintenance therapy. The final stage therapy is the most important part of the regime that last for approximately two years and targeted to remove residual leukemic cell population. To achieve long term leukemia free survival detection of residual leukemic cell in bone marrow level is essential. Again in the treatment of leukemia removal of leukemic cell is not the major issue rather sustenance of the normal cell population is the biggest challenge. A delay ordinary differential equation (DODE) based model is developed for chemotherapeutic dosing optimization so that residual leukemic cell population is removed along with the maintenance of normal cell population. With the chemotherapeutic maintenance therapy in ALL patients' data, here we show that the model can aptly be fitted with the real life clinical scenario.