首页> 外国专利> aqueous red cell storage composition red blood cell suspension, red blood cell preservation method (rbc`s) during a storage period, red blood cell membrane maintenance method or red blood cell maintenance red blood cells (rbc) and suppression of rbc`s apoptosis during a storage period, method for reducing red cell fragility (rbc`s) and suppression of rbc`s hemolysis during a storage period, Method to increase red cell viability (rbc`s), Red cell preservation (rbc`s) method during a storage period, combination, and aqueous composition

aqueous red cell storage composition red blood cell suspension, red blood cell preservation method (rbc`s) during a storage period, red blood cell membrane maintenance method or red blood cell maintenance red blood cells (rbc) and suppression of rbc`s apoptosis during a storage period, method for reducing red cell fragility (rbc`s) and suppression of rbc`s hemolysis during a storage period, Method to increase red cell viability (rbc`s), Red cell preservation (rbc`s) method during a storage period, combination, and aqueous composition

机译:水性红细胞储存组合物红细胞悬浮液,储存期的红细胞保存方法(rbc`s),红细胞膜维持方法或红细胞维持红细胞(rbc)和抑制rbc在过程中的凋亡贮藏期,在贮藏期中减少红细胞脆性(rbc`s)和抑制rbc's溶血的方法,增加红细胞生存力(rbc`s)的方法,在贮藏期间的红细胞保存(rbc`s)方法储存期,组合和水性成分

摘要

WATER COMPOSITION FOR HEMACY STORAGE, HEMACY SUSPENSION, RED BLOOD CELLS (RBC'S) PRESERVATION METHOD DURING A HEMACHEMATIC HEMACHEMATIC HEMAKE OR HEMATIC MEMBRANE PERIOD ("RED BLOOD CELLS" - RBC) AND RBC'S APOPTOSIS SUPPRESSION DURING A STORAGE PERIOD, HEMACY FRAGILITY REDUCTION METHOD (RBC'S) AND RBC'S HEMALYSIS SUPPRESSION FOR AMAZON AMAZIA PERIOD (RBC'S), HEMACY PRESERVATION METHOD (RBC'S) DURING A PERIOD OF STORAGE, COMBINATION, AND WATER COMPOSITION. The present invention proposes an aqueous red blood cell storage composition consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane proctor sugar; and a specifically defined pH buffer system. Improved methods for preserving red blood cells and methods for enhancing viability, membrane retention, and recoverability are also provided with the suppression of apoptosis, hemolysis, and post-infusion elimination of stored red blood cells using the new compositions.
机译:血细胞化学征象或血细胞膜时期(“红血细胞”-RBC)和RBC的凋亡(持续时间)期间血细胞保存,血细胞悬浮,红血细胞(RBC)的保存方法)以及在存储,组合和水组成期间的氨氮氨氮期(RBC's)的血红素抑制,血液保存方法(RBC'S)。本发明提出一种水性红细胞储存组合物,其基本上由以下组成:腺嘌呤;和葡萄糖;至少一种不可代谢的膜促进剂糖;以及专门定义的pH缓冲系统。使用新的组合物还提供了抑制红细胞保存的改进方法以及增强活力,膜保留和可恢复性的方法,从而抑制了细胞凋亡,溶血和输注后消除了储存的红细胞。

著录项

  • 公开/公告号BRPI0520102A2

    专利类型

  • 公开/公告日2009-04-22

    原文格式PDF

  • 申请/专利权人 UNIVERSITY OF CINCINNATI;

    申请/专利号BR2005PI20102

  • 发明设计人 JOHN R. HESS;

    申请日2005-02-17

  • 分类号A01N1;A01N1/02;A61K35/18;

  • 国家 BR

  • 入库时间 2022-08-21 19:28:30

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