Formulation for controlled release in the tympanic chamber of drug comprising N-acylated glycol chitosan

摘要

N-acylated glycol chitosan has amphiphilic properties, so it can support both hydrophilic and hydrophobic drugs, and a sol-gel phase transition occurs in the tympanic chamber, which can increase the residence time in the tympanic chamber, has no side effects, and can be used as a drug Depending on the type or concentration, the drug can be released in immediate or sustained release, so it can be useful for intratympanic drug delivery and treatment of inner ear diseases.