Compare drug release profiles of water poor soluble drugs from a novel chitosan and polycarbophil interpolyelectrolytes complexation (PCC) and hydroxylpropyl - methylcellulose (HPMC) based matrix tablets

摘要

The aim of this study was to compare the drug release behaviours of water poor soluble drugs from an interpolyelectrolyte complex(IPEC)of chitosan with polycarbophil(PCC)and hydroxylpropylmethylcellulose(HPMC)based matrix tablets. A novel interpoly-electrolyte complex(IPEC)of chitosan with polycarbophil(PCC)was synthesized and characterized. Water poor soluble drugs Hydrochlorothiazide and Ketoprofen were used in this study as model drugs. Polymers(including PCC，HPMC K100M and HPMC K100LV)based matrix tablets drug controlled release system were prepared using direct compression method. The results illustrate PCC based-matrix tablets offer a swelling controlled release system for water poor soluble drug and drug release mechanism from this matrix drug delivery system can be improved by addition of microcrystalline cellulose(Avicel). Analysis of the in vitro release kinetic parameters of the matrix tablets，PCC based matrix tablets exhibited similar or higher drug release exponent(n)and mean dissolution time(MDT)values compared to the HPMC based matrix tablets. It demonstrated that PCC polymer can be successfully used as a matrix controlled release system for the water poor soluble model drugs such as hydroxylpropylmethylcellulose(HPMC).