New porcine IFN-α fusion protein inhibiting foot-and-mouth disease and uses thereof

摘要

The present invention relates to a novel porcine interferon-alpha fusion protein having foot-and-mouth disease virus inhibitory activity and uses thereof, wherein the Fc region of a porcine antibody is linked to the N-terminus of a porcine interferon-alpha portion comprising a consensus sequence porcine interferon-alpha The fusion protein has improved stability and is maintained for a long time in vivo, and when mixed inoculation with foot-and-mouth disease oil vaccine, it rapidly inhibits foot-and-mouth disease virus and at the same time induces the generation of neutralizing antibodies within a short time, thereby preventing foot-and-mouth disease in the early stage. was confirmed.