The present invention relates to the technical field of medicine, and discloses an application of 2-bromopalmitic acid (2-BP) in preparation of a drug for prevention and treatment of a bone loss-related disease. In the present invention, by means of multiple experimental methods such as tartrate-resistant acid phosphatase staining, phalloidin fluorescent staining, bone plate bone resorption evaluation, reverse transcription real-time fluorescence-based quantitative PCR, and western blotting, it is made clear for the first time that 2-BP can inhibit an osteoclast differentiation process when BMMs are stimulated by RANKL. Moreover, by constructing an ovariectomized mouse osteoporosis model, it is made clear that 2-BP also has the function of inhibiting osteoclast differentiation and activation in vivo, and can significantly alleviate the pathological process of a large bone loss caused by estrogen deficiency; a in vivo experimental data basis for 2-BP in prevention and treatment of bone loss-related diseases is provided.
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