MMP-9 AND MMP-12 INHIBITION FOR TREATING SPINAL CORD INJURY OR RELATED INJURY TO NEUROLOGICAL TISSUE

摘要

The use of a single compound or a combination of compounds which selectively inhibit both matrix metalloproteinases MMP-9 and MMP-12 in treating spinal cord injury (SCI), the secondary effects of SCI and related injury to neurological tissue are described, in particular the suppression of SCI- induced oedema, treatment of neuropathic pain, the prevention of functional decline following SCI and methods of administration.