Anti vegf-anti-pd1 dual specificity antibody of a novel structure

摘要

A new type of anti vegf-anti-pd1 dual specificity antibody is provided.Anti vegf-anti-pd1 dual specificity antibody of the new structure belongs to the technology of the molecular immunology.Cdr-h1 of the heavy chain variable region of the antibody is an amino acid sequence represented by SEQ ID No: 1, cdr-h2 is an amino acid sequence represented by SEQ ID No: 2, and CDR-H3 is an amino acid sequence expressed by SEQ ID NO Cdr-l of the light chain variable region of the antibody is an amino acid sequence represented by SEQ ID No: 4.The dual specificity antibody ps3vm isCan be effectively combined with PD-1 and VEGF proteinsIt effectively associates with PDL-1 and binds to the PD-1 proteinSimultaneously with VEGF-A, it can compete with VEGF protein effectively, andEffectively stimulating T cell functionCytokines IL-2 and IFN - γ Can be secretedIsotype control antibodyT cell proliferation and IL-2IFN γ Can not promote secretion.The dual specific antibody ps3vm can also positively inhibit tumor growth in mice.Diagram