Interleukin-2 receptor (IL2R) and interleukin-2 (IL2) variants for specific activation of immune effector cells

摘要

The present invention relates to the alpha subunit of interleukin-2 receptor (IL2R) and variants of interleukin-2 (IL2). In one embodiment, the IL2 variants described herein have an amino acid substitution in the region of IL2 in contact with the heterotrimeric IL2 receptor complex, the alpha (α) subunit of IL2Rαβγ, such that the ability to bind and activate the heterotrimeric receptor complex is reduced. . Conversely, the corresponding IL2Rα variants described herein are amino acids contacted by amino acid substitutions that compensate for the reduced ability of such IL2 variants to bind and activate IL2Rαβγ, preferably the IL2 amino acid residues substituted in the IL2 variants described herein. have a substitution.