HUMAN INTERLEUKIN-2 MUTANT WHICH ACTIVATES PREFERABLY T-CELLS AS COMPARED WITH NATURAL KILLER CELLS, PHARMACEUTICAL COMPOSITION, POLYNUCLEOTIDE, VECTOR, PROCARIOTIC CELL, A METHOD FOR THE STIMULATION OF IMMUNE SYSTEM

摘要

The invention concerns the human interleukin -2 mutant numerated according to the wild type of interleukin -2, which has an aminoacid substitution in one or two positions with 20, 88 and 126, said mutants activate preferably T-cells as compared with natural killer cells and have smaller toxicity. The invention concerns also polynucleotide coding said interleukin -2 mutant, vector and cell which include said polynucleotide, pharmaceutical composition and a method for stimulation of immune system.