The present invention relates to an exosome miRNA panel marker composition for early-stage cancer diagnosis for non-invasive in vitro diagnosis. In order to find a new serum liver cancer biomarker, the microRNA inside the exosome secreted by liver cancer cells is analyzed to be specific in the liver cancer exosome. By identifying microRNAs that are overexpressed with , a new serum biomarker with high diagnostic accuracy was discovered in early liver cancer, where there are currently no reliable biomarkers. As such, by using exosomes to identify the cancer cell genome and proteomic without biopsy, it is highly likely to be utilized as a useful diagnostic biomarker in a disease group with a high risk of biopsy, such as liver cancer in the future.
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