The present invention relates to an exosome miRNA panel marker composition for early stage cancer diagnosis for non-invasive in vitro diagnosis, by analyzing microRNA inside exosomes secreted by liver cancer cells to find new serum liver cancer biomarkers, specific in liver cancer exosomes By identifying microRNAs that are overexpressed with, we discovered a new serum biomarker with high diagnostic accuracy in early liver cancer, which currently lacks a reliable biomarker. As described above, since exosomes are used to identify cancer cell genomes and proteins without tissue examination, it is highly likely to be used as a useful diagnostic biomarker in disease groups with a high risk of tissue examination, such as liver cancer in the future.
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