A CRITICAL ROLE OF FEBRILE TEMPERATURE IN REGULATING INTERLEUKIN (IL) -17 PRODUCING CELLS VIA SMAD4

摘要

Provided is a method of promoting the differentiation or maturation of an IL-17 producing cell, promoting a production of IL-17, improving an immunity of a patient or reducing an immunity of a patient, the method comprises: allowing differentiation or maturation of an IL-17 producing cell under a condition with an environmental temperature higher than a normal body temperature; allowing differentiation or maturation of an IL-17 producing cell lower than a febrile temperature; allowing differentiation or maturation of an IL-17 producing cell in the presence of an inhibitor for SMAD4; allowing differentiation or maturation of an IL-17 producing cell in the presence of an inhibitor for SUMOylated SMAD4; allowing differentiation or maturation of an IL-17 producing cell in the presence of an inhibitor for UBC9; allowing differentiation or maturation of an IL-17 producing cell in the presence of an inhibitor for HSP70; allowing differentiation or maturation of an IL-17 producing cell in the presence of an inhibitor for HSP90; allowing differentiation or maturation of an IL-17 producing cell in the presence of an activator for SMAD4; allowing differentiation or maturation of an IL-17 producing cell in the presence of an activator for SUMOylated SMAD4; allowing differentiation or maturation of an IL-17 producing cell in the presence of an activator for UBC9; allowing differentiation or maturation of an IL-17 producing cell in the presence of an activator for HSP70; allowing differentiation or maturation of an IL-17 producing cell in the presence of an activator for HSP90.