Inhibition of the production of proinflammatory cytokine interleukin-17 (IL-17) by T cells, using an antagonist of interleukin-23 (IL-23)

摘要

Disclosed is the use of an antagonist of interleukin-23 (IL-23) for the manufacture of a medicament for the treatment of a bacterial infection or an inflammatory disease characterised by elevated expression of IL-17. The antagonists are selected from an anti-IL-23 and an anti-IL-23 receptor antibody. Further disclosed are products containing such antibodies, and methods for identifying anti-inflammatory agents by incubating T cells with IL-23 and monitoring the level of IL-17.